人白細胞介素-6受體|Human IL-6 Receptor

Synonyms :

soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Description :

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R α and gp130. The IL-6R α chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R α. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R α alone. IL-6R α is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R α which consists of only the extracellular domain of the IL-6R α chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R α is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R α chain (338 amino acid residues).

Catalog #:

200-06R

Source :

HEK 293 cells

Stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20⁰C. Reconstituted sIL-6R α is stable for at least 3 months when stored in working aliquots with a carrier protein at -20⁰C. Avoid repeated freeze/thaw cycles.

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

The ED₅₀ was determined by it's ability to intensify the IL-6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Selected References :

Selected List of References Citing This PeproTech Product

AA Sequence :

LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH ASGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPAPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD

PubMed Link :

IL-6+AND+receptor-alpha

Country of Origin :

USA