產品名稱：人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO
產品規格：
單 位：瓶
關 鍵 字：人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO
CANSPEC品質提供的人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO性能**，英文名稱人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO，簡稱為人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO，中文名稱為人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO。
產品人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO以其優良的品質滿足您不同實驗的多種需求。并保證每批人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO的質量和人類轉化生長因子-β1（膽固醇氧化酶）|Human TGF-beta1-Produced in CHO品質優良。Synonyms :Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factorDescription :The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Catalog #:100-21CSource :CHO cells* *Made using a license from PHS, NIH. Patent Pending.Stability :The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.Purity :Greater than 98% by SDS-PAGE gel and HPLC analysesEndotoxin Level :Endotoxin level is less than 0.1 ng per μg (1EU/μg).Biological Activity :The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mgSelected References :Selected List of References Citing This PeproTech ProductAA Sequence :ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS PubMed Link :TGF+AND+beta+AND+1Country of Origin :USA
Synonyms :
Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factor
Description :
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Catalog #:
100-21C
Source :
CHO cells* *Made using a license from PHS, NIH. Patent Pending.
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
PubMed Link :
TGF+AND+beta+AND+1
Country of Origin :
USA
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