重組人 FGF21 蛋白|Fibroblast Growth Factor 21 / FGF21 Protein|產品詳情|現貨

FGF21蛋白產品信息
產品名稱：重組人 FGF21 蛋白|Fibroblast Growth Factor 21 / FGF21 Protein|產品詳情|現貨
別名: UNQ3115   /   PRO10196
表達方式: A DNA sequence encoding the mature form of human FGF21 ( NP_061986.1 ) ( His 29 - Ser 209 ) was expressed, with a polyhistide tag at the N-terminus
種屬: Human
表達宿主: E. coli
FGF21蛋白質控指標
純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: Please contact us for more information.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: The recombinant human FGF21 consisting of 188 amino acids and has a calculated molecular mass of 20.2 kDa. It migrates as an 23 kDa band in SDS-PAGE under reducing conditions as predicted
緩沖液: Lyophilized from 50 mM Tris, 10 % glycerol, 0.05 % Brig 35, pH 8.0
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FGF21蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FGF21蛋白背景綜述
The fibroblast growth factors (FGFs) are a growing family of heparin-binding growth factors that regulate a variety of physiological processes in both developing and ***** organism. FGFs function as key secreted signalling molecules in many developmental events. Fibroblast growth factor 21 (FGF21) is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control. FGF21 functions as a metabolic regulator. The FGF21 transcript is abundantly expressed in liver. FGF21 activity depends on membrane protein betaKlotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF21 and activate downstream signaling pathways. FGF21, like other FGFs, folds to a beta-trefoil-like core region, with disordered N- and C-termini. FGF21 recently has been proposed as a missing link in the biology of fasting, it shows significant, non-saturable, unidirectional influx across the blood-brain barrier (BBB). FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. FGF21 circulates in human plasma and increases by extreme fasting and PPARalpha activation. The wide interindividual variation and the induction of ketogenesis independent of FGF21 levels indicate that the physiological role of FGF21 in humans may differ from that in mice.
參考文獻
Hsuchou, H. et al., 2007, Peptides. 28 (12): 2382-6.
Yamauchi,H. et al., 2006, EMBO Rep. 7 (6): 649-54.
Izumiya,Y. et al., 2008, FEBS Lett 582 (27): 3805-10.
Arner,P. et al., FEBS Lett 2008, 582 (12): 1725-30.
Micanovic,R. et al., 2009, J Cell Physiol. 219 (2): 227-34.

包裝：20ug

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