重組人 FGF18 / FGF-18 蛋白|Fibroblast growth factor 18 Protein|產品詳情|現貨|價格

FGF18 / FGF-18蛋白產品信息
產品名稱：重組人 FGF18 / FGF-18 蛋白|Fibroblast growth factor 18 Protein|產品詳情|現貨|價格
別名: UNQ420, PRO856, FGF-18, ZFGF5
表達方式: A DNA sequence encoding the human FGF18 (O76093) (Met 1- Ala 207) was fused with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells
FGF18 / FGF-18蛋白質控指標
純度: >92 % as determined by SDS-PAGE.  SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu 28
分子量: The secreted recombinant human FGF18 comprises 191 amino acids and has a predicted molecular mass of 22.3 kDa. The apparent molecular mass of rh FGF18 is approximately 32 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
FGF18 / FGF-18蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FGF18 / FGF-18蛋白背景綜述
Fibroblast growth factor 18, also known as FGF-18, and FGF18, is a secreted protein which belongs to the fibroblast growth factors (FGFs) family. FGFs and their high-affinity receptors contribute to the autocrine growth stimulation in several malignancies. FGF18 is abundantly expressed in mouse embryonic lungs. It plays roles in lung alveolar development during late embryonic lung development stages. The cell proliferation during the terminal saccular stage stimulated by FGF18 might play roles in the remodeling of the distal lung. FGF18 expression is up-regulated in colorectal tumours and is progressively enhanced during colon carcinogenesis reaching very high levels in carcinoma. FGF18 affects both tumour cells and tumour microenvironment in a pro-tumorigenic and pro-metastatic way. FGF18 is almost generally over-expressed in colon cancer and exerts pro-tumorigenic effects both in the epithelial and the stromal compartments by stimulating growth and survival of tumour cells, migration of fibroblasts and neovascularization. FGF18 has been shown to regulate chondrocyte proliferation and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by signaling through other FGFRs. FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts / osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. FGF18 coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation.
參考文獻
Ohbayashi N. et al., 2002, Genes Dev. 16 (7): 870-9.
Usui H. et al., 2004, Biochem Biophys Res Commun. 322 (3): 887-92.
Liu Z. et al., 2007, Dev Biol. 302 (1): 80-91.
Reinhold MI. et al., 2007, J Biol Chem. 282 (6): 3653-63.
Sonvilla G. et al., 2008, Carcinogenesis. 29 (1):15-24.

包裝：20ug

1、產品質量問題，在產品售出7日內提出異議并且產品未有損壞，試劑類產品，需要提供詳細的檢測數據，創賽負責免費退換貨服務；
2、本產品屬于消耗品，不提供質保服務；
3、所有產品售后問題，請直接聯系我司，我們將會盡快為您響應處理
查詢關鍵詞：重組人 FGF18 / FGF-18 蛋白，Fibroblast growth factor 18 Protein，產品詳情，現貨，價格，原料藥，大包裝定制，現貨促銷，醫藥中間體，科學儀器，實驗室耗材，生化試劑，創賽中國,細胞因子
CANSPEC品質提供的重組人 FGF18 / FGF-18 蛋白|Fibroblast growth factor 18 Protein|產品詳情|現貨|價格性能**，其優良的品質滿足您不同實驗的多種需求。
本產品由上海創賽品質提供，歡迎咨詢國內免費服務專線：400-608-7598，更多產品信息請登錄m.aysxmc.cn或www.4006087598.com