FGF12蛋白產品信息 產品名稱:重組狗 FGF12 蛋白|Fibroblast growth factor 12 Protein|技術資料|參數 別名: FGF12 表達方式: A DNA sequence encoding the canine FGF12 (Glu2-Thr181) was expressed with a N-terminal Met. 種屬: Canine 表達宿主: E.coli FGF12 Protein QC Testing 純度: > 90% as determined by SDS-PAGE SDS-PAGE 內**: Please contact us for more information. 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Met 分子量: The recombinant canine FGF12 comprises 181 amino acids and has a predicted molecular mass of 20.4 kDa. The apparent molecular mass of the protein is approximately 20 kDa in SDS-PAGE under reducing conditions due to glycosylation. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. FGF12蛋白背景綜述 FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. The specific function of FGF12 gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. 參考文獻 Liu Y. et al., 1997, Cytogenet Cell Genet. 78 (1): 48-9. Robertson NG. et al., 1995, Genomics. 23 (1): 42-50. Smallwood PM. et al., 1996, Proc Natl Acad Sci. 93 (18): 9850-7. 包裝:20ug
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