重組狗 EGF / Epidermal Growth Facto 蛋白|Epidermal growth factor Protein |參數|現貨

EGF / Epidermal Growth Facto蛋白產品信息
產品名稱：重組狗 EGF / Epidermal Growth Facto 蛋白|Epidermal growth factor Protein |參數|現貨
別名: CEGF
表達方式: A DNA sequence encoding the mature form of canine EGF (Q9BEA0) (Asn 973-Arg 1024) was fused with a polyhistidine tag at the N-terminus.
種屬: Canine
表達宿主: E.coli
EGF / Epidermal Growth Facto蛋白質控指標

純度: > 98 % as determined by SDS-PAGE.  SDS-PAGE
內**: Please contact us for more information.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: The recombinant canine EGF consists of 68 amino acids and has a calculated molecular mass of 8.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of canine EGF is approximately 12 kDa.
緩沖液: Lyophilized from sterile PBS, pH7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EGF / Epidermal Growth Facto蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EGF / Epidermal Growth Facto蛋白背景綜述
Canine epidermal growth factor (EGF), also known as urogastrone (URG) since it was isolated from urine based on its inhibitory effect on gastric secretion, is the founding member of the EGF-family of growth factors. All the members of this protein family have highly similar structural and functional characteristics. EGF is initially synthesized as a 130 kDa single-pass transmembrane protein containing 9 EGF-like units and 9 LDL-receptor class B repeats. The mature soluble EGF is a 6 kDa peptide corresponding to the EGF unit located proximal to the transmembrane domain. EGF is expressed in kidney, salivary gland, cerebrum and prostate, and plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. As a potent mitogen, EGF stimulates the growth of various epidermal and epithelial tissues both in vivo and in vitro. Furthermore, EGF is also identified as a magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4), a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion.
參考文獻
Ciardiello F. et al., 1991, Proc Natl Acad Sci. 88: 7792-7796.
Gout I. et al., 1992, Biochem J. 288: 395-405.
Harris RC. et al., 2003, Exp Cell Res. 284: 2-13.
Dreux AC. et al., 2006, Atherosclerosis. 186: 38-53.
Groenestege WMT. et al., 2007, J Clin Invest. 117: 2260-2267.

包裝：100ug  200ug

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查詢關鍵詞：重組狗 EGF / Epidermal Growth Facto 蛋白，Epidermal growth factor Protein ，參數，現貨，原料藥，大包裝定制，現貨促銷，醫藥中間體，科學儀器，實驗室耗材，生化試劑，創賽中國,細胞因子
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