重組人 Amphiregulin 蛋白|Amphiregulin Protein|技術資料|參數

Amphiregulin蛋白產品信息
產品名稱：重組人 Amphiregulin 蛋白|Amphiregulin Protein|技術資料|參數
別名: AR, AREGB, CRDGF, MGC13647, SDGF
表達方式: A DNA sequence encoding the mature form of human AREG (P15514-1) (Ser 101-Lys 198) was expressed and purified, with an initial Met at the N-terminus.
種屬: Human
表達宿主: E.coli

Amphiregulin Protein QC Testing
純度: > 92 % as determined by SDS-PAGE SDS-PAGE
內**: Please contact us for more information.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: The recombinant human AREG consisting of 99 amino acids and has a predicted molecular mass of 11.4 kDa. It migrates as an approximately 17KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.5.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Amphiregulin Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Amphiregulin蛋白背景綜述
Amphiregulin, also known as colorectum cell-derived growth factor, CRDGF, SDGF and AREG, is a single-pass membrane protein which belongs to the amphiregulin family. Amphiregulin ( AREG / SDGF ) is essential for epithelial development in various organs. It contains one EGF-like domain. Amphiregulin ( AREG / SDGF ) is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AREG / SDGF is a bifunctional growth-modulating glycoprotein. It inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. Amphiregulin ( AREG / SDGF ) protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. It is associated with a psoriasis-like skin phenotype. Amphiregulin ( AREG / SDGF ) treatment enhanced the activation of Akt and Erk in lung epithelial cells. Amphiregulin may play a protective role in bleomycin-induced pneumopathy, probably through the activation of survival signals. Administration of amphiregulin may be a novel therapeutic strategy against lung injury and fibrosis.
參考文獻
Plowman GD. et al., 1990, Mol Cell Biol. 10: 1969-81.
Falk A. et al., 2002, J Neurosci Res. 69 (6): 757-62.
Hurbin A. et al., 2003, J Biol Chem. 277 (51): 49127-33.
Sekiguchi T. et al., 2004, J Mol Endocrinol. 33 (1): 281-91.
Willmarth NE. et al., 2008, J Mammary Gland Biol Neoplasia. 13 (2): 171-9.
Fukumoto J. et al., 2010, Am J Physiol Lung Cell Mol Physiol. 298 (2): 131-8.

包裝：100ug

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