重組人 CXCL4 / PF4 蛋白|Platelet Factor 4 (Chemokine (C-X-C Motif) Ligand 4) Protein

CXCL4 / PF4蛋白產品信息
產品名稱：重組人 CXCL4 / PF4 蛋白|Platelet Factor 4 (Chemokine (C-X-C Motif) Ligand 4) Protein
別名: PF4, CXCL4, MGC138298, SCYB4
表達方式: A DNA sequence encoding the human CXCL4 ( NP_002610.1 ) ( Glu 32 - Ser 101 ) was expressed.
種屬: Human
表達宿主: E.Coli

CXCL4 / PF4 Protein QC Testing
純度: > 80 % as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its ability to inhibit human bFGF / FGF2 dependent proliferation of  Balb/c3T3  mouse fibroblasts
The ED50 for this effect is typically  5-40 μg/mL
Measured by its binding ability in a functional ELISA
Immobilized human CXCL4 at 20 μg/mL ( 100 μl/well ) can bind biotinylated human VEGF165
The EC50 of biotinylated human VEGF165 is  9.97 μg/mL
內**: Please contact us for more information..
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: The recombinant human CXCL4 comprises 71 amino acids with a predicted molecular mass of 7.8 kDa. It migrates as an approximately 11-15 kDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL4 / PF4 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL4 / PF4蛋白背景綜述
Platelet factor 4 (PF4) is a 70-amino acid protein belonging to the CXC chemokine family also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . It is released from the alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 plays a critical role in inflammation and wound repair. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.
參考文獻
Deuel, T.F. et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4584–4587.
Eisman, R. et al., 1990, Blood. 76 (2): 336–344.
O'Donovan, N. et al.,1999, Cytogenet Cell Genet. 84 (1-2): 39–42.
Lasagni, L. et al.,2003, J Exp Med.197 (11): 1537–1549.
Warkentin, T. E., 2007, N. Engl. J. Med. 356 (9): 891–893.
Warkentin, T. E, et al., 2008, Am. J. Med. 121 (7): 632–636.

包裝：5ug  25ug 

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查詢關鍵詞：重組人 CXCL4 / PF4 蛋白，Platelet Factor 4 (Chemokine (C-X-C Motif) Ligand 4) Protein，原料藥，大包裝定制，現貨促銷，醫藥中間體，科學儀器，實驗室耗材，生化試劑，創賽中國,細胞因子
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