重組食蟹猴 CXCL13 / BCA-1 / BLC 蛋白|Cynomolgus CXCL13 / BCA-1 Protein|產品詳情|價格

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Cynomolgus CXCL13 / BCA-1蛋白產品信息
產品名稱：重組食蟹猴 CXCL13 / BCA-1 / BLC 蛋白|Cynomolgus CXCL13 / BCA-1 Protein|產品詳情|價格
別名: cxcl13
表達方式: A DNA sequence encoding the mature form of Cynomolgus ( Macaca fascicularis ) CXCL13 ( Val 23 - Pro 109 ) was expressed, with an N-terminal polyhistidine tag
種屬: Cynomolgus
表達宿主: E.coli

Cynomolgus CXCL13 / BCA-1蛋白質控指標
純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: Please contact us for more information.
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: His
分子量: The recombinant cynomolgus CXCL13 consists of 103 amino acids and has a calculated molecular mass of 12.4 kDa. The apparent molecular mass of the recombinant protein is approximately 14 kDa in SDS-PAGE under reducing conditions due to glycosylation
緩沖液: Lyophilized from sterile 10 mM Tris, 250mM  NaCl, pH 8.0
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Cynomolgus CXCL13 / BCA-1蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Cynomolgus CXCL13 / BCA-1蛋白背景綜述
Cynomolgus CXCL13, also known as BCA-1 ( B-cell-attracting chemokine-1 ) or BLC ( B-lymphocyte chemoattractant ), is a major regulator of B-cell trafficking. CXCL13 is a small cytokine belonging to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. The increased level of CXCL13 is a feature of systemic lupus erythematosus (SLE) that correlates with disease activity. Furthermore, CXCL13 might be a readily available surrogate marker to monitor the extent of aberrant B-cell (dys-)function. The vascular endothelial BCA-1 expression may be consequent to transcytosis. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). CXCL13 expression is a distinctive feature of angioimmunoblastic T-cell lymphoma, providing further support for the germinal center T-helper cell as the cell of origin for this neoplasm. Furthermore, CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.

參考文獻
Ansel KM. et al., 2000, Nature. 406 (6793): 309-14.
Schiffer L. et al., 2009, Nephrol Dial Transplant. 24(12): 3708-12.
Rupprecht TA. et al., 2009, J Neuroinflammation. 6: 42.
Smith JR. et al., 2003, Blood. 101(3): 815-21.
Grogg KL. et al., 2006, Mod Pathol. 19(8): 1101-7.
Falkenhagen KM. et al., 2005, Am J Ophthalmol. 140(2): 335-7.

包裝：20ug

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