重組人 ANG2 / Angiopoietin-2 蛋白|Angiopoietin-2 / ANG2 Protein|參數|技術資料

Angiopoietin-2 / ANG2蛋白產品信息
產品名稱：重組人 ANG2 / Angiopoietin-2 蛋白|Angiopoietin-2 / ANG2 Protein|參數|技術資料
別名: AGPT2,   ANG2,   ANGPT2
表達方式: 
A DNA sequence encoding the human Angiopoietin 2 ( NP_001138.1 ) ( Met 1 -  Phe 496 ) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

Angiopoietin-2 / ANG2蛋白質控指標
純度: > 92 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Tyr 19
分子量: The recombinant human Ang2 consists of 489 amino acids and predicts a molecular mass of 56.3 kDa. As a result of glycosylation, the rhAng2 migrates as approximately 60-70 kDa band in SDS-PAGE under reducing conditions
緩沖液: 
Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Angiopoietin-2 / ANG2蛋白使用指南

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Angiopoietin-2 / ANG2蛋白背景綜述
Angiopoietin 2 (Ang2), closely related to Ang1, is a secreted ligand which binds to the endothelial-specific receptor tyrosine kinase Tie2 with similar affinity. Ang2 is a soluble 70kd growth factor consisting of an amino-terminal coiled-coil domain and a carboxy-terminal fibrinogen-like domain. Tie2 and angiopoietins have been shown to play critical roles in vessel remodeling during angiogenesis, vascular homeostatic responses, and the ***** vasculature integrity. Ang2 was initially characterized as an antagonist of Ang1 and Tie2, which competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis.
參考文獻
Maisonpierre, P.C. et al., 1997, Science 277: 55-60
Bezuidenhout, L. et al., 2007, J. Leukoc. Biol. 81: 1496-1503.
Tanaka, S. et al., 1999, J. Clin. Invest. 103: 341-345.
Yu, Q. et al., 2001, Am. J. Pathol. 158: 563-570.
Teichert-Kuliszewska, K. et al., 2001, Circ. Res. 49, 659-670.
Schliemann, C. et al., 2007, Leukemia. 21: 1901-1906.

包裝：20ug

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