重組大鼠 LTBR 蛋白|LTBR Protein|技術資料|現貨

LTBR蛋白產品信息
產品名稱：重組大鼠 LTBR 蛋白|LTBR Protein|技術資料|現貨
別名: LTBR
表達方式: 
A DNA sequence encoding the rat LTBR (NP_001008316.1 ) extracellular domain (Met 1-Ala 218) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

LTBR蛋白質控指標
純度: > 96 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ser 28
分子量: The recombinant rat LTBR comprises 202 amino acids and predicts a molecular mass of 23 kDa. The apparent molecular mass of the ratLTBR is approximately 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LTBR蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LTBR蛋白背景綜述
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) contains 4 TNFR-Cys repeats and belongs to the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. It is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. LTBR has been shown to interact with diablo homolog and TRAF3. It can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release. It specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells.
參考文獻
Summers deLuca L. et al., 2011, Proc Natl Acad Sci. 108 (5): 2046-51.
Bista P. et al., 2010, J Biol Chem. 285 (17): 12971-8.
Xu Y. et al., 2011, Biochem Biophys Res Commun. 404 (4): 1060-4.
包裝：50ug

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