重組小鼠 TWSG1 蛋白|Twisted gastrulation homolog 1 (Drosophila) Protein|廠家價格|現貨

WSG1蛋白產品信息

產品名稱：重組小鼠 TWSG1 蛋白|Twisted gastrulation homolog 1 (Drosophila) Protein|廠家價格|現貨
別名: 1810013J15Rik, 9030422N06Rik, AW552143, D17Ertd403e, Tsg, Twg
表達方式: A DNA sequence encoding the mouse TWSG1 (Q9EP52) (Met 1-Phe 222) was expressed, with a C-terminal polyhistidine tag.
種屬: Mouse
表達宿主: Human Cells

TWSG1 Protein QC Testing
純度: > 93 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Cys 25
分子量: The secreted recombinant mouse TWSG1 comprises 209 amino acids and has a calculated molecular mass of 23.6kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 34 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TWSG1 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TWSG1蛋白背景綜述
TWSG1 is a member of the twisted gastrulation protein family. Expression of TWSG1 is found throughout mouse and human development. Overexpression of TWSG1 in transgenic mice under the control of the cartilage-specific promoter significantly reduces collagen type 10 expression in the growth plates of transgenic embryos. TWSG1 is a secreted binding protein for various bone morphogenetic proteins (BMP). Depending upon the circumstances it may function as a bone morphogenetic protein signalling agonist or antagonize these activities. TWSG1 can dislodge latent bone morphogenetic proteins and thus provides a permissive signal that allows high BMP signaling in the embryo. Activities of TWSG1 and complexed bone morphogenetic proteins are influenced also by binding of another regulatory protein, BMPER, which may function to concentrate diffusible complexes between TWSG1 and bone morphogenetic proteins. TWSG1 may be involved in dorsoventral axis formation. It seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.
參考文獻
Tzachanis D. et al., 2007, J Immunol. Blood. 109 (7): 2944-52.
Tanno T. et al., 2009, Blood. 114 (1): 181-6.
Kauvar EF. et al., 2011, Mol Genet Metab. 102 (4): 470-80.

包裝：50ug

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查詢關鍵詞：重組小鼠 TWSG1 蛋白，Twisted gastrulation homolog 1 (Drosophila) Protein，廠家價格，現貨，原料藥，大包裝定制，現貨促銷，醫藥中間體，科學儀器，實驗室耗材，生化試劑，創賽中國,細胞因子
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