重組大鼠 IL18R1 蛋白|技術資料|參數|價格

IL18R1蛋白產品信息

別名: IL18R1
表達方式: A DNA sequence encoding the rat IL18R1 (NP_001100375.1) extracellular domain (Met 1-Gly 326) was fused with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達宿主: Human Cells

IL18R1 Protein QC Testing

純度: > 97 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 18
分子量: The recombinant rat IL18R1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 550 amino acids and predicts a molecular mass of 62.5kDa. The apparent molecular mass of the rat IL18R1/Fc monomer is approximately 105 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL18R1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL18R1蛋白背景綜述

The interleukin-18 receptor 1 (IL18R1), also known as CDw218a (cluster of differentiation w218a), is a cytokine receptor that belongs to the interleukin 1 receptor family, and a single-pass type I membrane protein contining three Ig-ike C2-type domains within the ECD. It specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction, and it is reported that binding to the agonist leads to the activation of NF-kappa-B. IL-18 receptor was first described in 1989. It induces synthesis and release of IFN-gamma, IL- 8, 4 and 13, TNF-alpha and granulocyte/macrophage colony stimulating factor (GM-CSF). It modulates the function of many immunocompetent cells including macrophages, monocytes, lymphocytes and granulocytes. Another feature of IL-18 receptor is its ability to induce apoptosis of many cell types by inducing Fas ligand and receptor, aas well as granzymes. High level of IL18R1 expression is detected in Hodgkin's disease cell lines.

參考文獻

Dale M. et al., 1999, Genomics. 57(1): 177-9.
Sergi B. et al., 2004, J Biol Regul Homeost Agents. 18 (1): 55-61.
Wereszczy ska SU. et al., 2004, Pol Merkur Lekarski.16 (93): 279-81.

規格：50ug

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